The key to optimizing efficiency and reducing the environmental impact of all mineral processing – in particular, comminution - lies in innovative flowsheets. This presentation will explore best practices in layout design for technologies such as the HPGR (High Pressure Grinding Roll) and vertical stirred mills, ensuring high operability and maintainability for both Green and Brownfield operations. Further, it will de-risk adoption concerns across the various project stages with process validation experiences. The overall energy savings of this flowsheet accumulate to a sum much larger than its individual process equipment units, resulting in significant operational cost savings for its adopters – and a more sustainable future for all.